BAT Expansion: A Panacea against Obesity? Lessons from LKB1
نویسنده
چکیده
Article history: Received 26 September 2017 Accepted 26 September 2017 Available online 28 September 2017 onine kinase 11 (STK11), commonly known as liver kinase B1 (LKB1), specifically in adipocytes (Xiong et al., 2017). LKB1 plays important roles in various biological processes including cellular energy metabolism, where it acts as the main upstream activating kinase of AMPactivated protein kinase (AMPK) (López et al., 2016). Previous seminal work from the same authors demonstrated that deletion of LKB1
منابع مشابه
Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
Brown adipose tissue (BAT) dissipates energy through Ucp1-mediated uncoupled respiration and its activation may represent a therapeutic strategy to combat obesity. Here we show that Lkb1 controls BAT expansion and UCP1 expression in mice. We generate adipocyte-specific Lkb1 knockout mice and show that, compared with wild-type littermates, these mice exhibit elevated UCP1 expression in BAT and s...
متن کاملPeripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1
Brown adipose tissues (BAT) burn lipids to generate heat through uncoupled respiration, thus representing a powerful target to counteract lipid accumulation and obesity. The tumor suppressor liver kinase b1 (Lkb1) is a key regulator of cellular energy metabolism; and adipocyte-specific knockout of Lkb1 (Ad-Lkb1 KO) leads to the expansion of BAT, improvements in systemic metabolism and resistanc...
متن کاملA Larger BAT Improves Metabolism but Whiffs on Safety
https://doi.org/10.1016/j.ebiom.2017.09.036 2352-3964/Published by Elsevier B.V. This is an open acce Obesity is at epidemic levels in many countries worldwide, largely due to deleterious lifestyle and dietary factors. For instance, in theUnited States over a third of adults are obese and another third are overweight; childhood obesity is also disturbingly prevalent (Flegal et al., 2016). Given...
متن کاملMicroRNA-378 controls classical brown fat expansion to counteract obesity
Both classical brown adipocytes and brown-like beige adipocytes are considered as promising therapeutic targets for obesity; however, their development, relative importance and functional coordination are not well understood. Here we show that a modest expression of miR-378/378* in adipose tissue specifically increases classical brown fat (BAT) mass, but not white fat (WAT) mass. Remarkably, BA...
متن کاملBrown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure
We recently reported that local overexpression of VEGF-A in white adipose tissue (WAT) protects against diet-induced obesity and metabolic dysfunction. The observation that VEGF-A induces a "brown adipose tissue (BAT)-like" phenotype in WAT prompted us to further explore the direct function of VEGF-A in BAT. We utilized a doxycycline (Dox)-inducible, brown adipocyte-specific VEGF-A transgenic o...
متن کامل